Muscle relaxant less sedating
For this reason, the use in conscious sedation in children less than 6 months of age is not recommended.
The dose must be reduced and individualised when midazolam is administered to adults over 60 years of age, debilitated, or chronically ill patients. dose is 0.5 mg and should be slowly uptitrated as needed.A total dose up to 0.6 mg/kg may be necessary to reach the desired endpoint, but the total dose should not exceed 6 mg.Prolonged sedation and risk of hypoventilation may be associated with the higher doses.• CONSCIOUS SEDATION before and during diagnostic or therapeutic procedures with or without local anaesthesia.• ANAESTHESIA – Premedication before induction of anaesthesia – Induction of anaesthesia – As a sedative components in combined anaesthesia • SEDATION IN INTENSIVE CARE UNITS • CONSCIOUS SEDATION before and during diagnostic or therapeutic procedures with or without local anaesthesia.Adults over 60 years of age In adults over 60 years of age, debilitated or chronically ill patients, the initial dose must be reduced to 0.5-1.0 mg and given 5-10 minutes before the beginning of the procedure.
Further doses of 0.5 to 1 mg may be given as necessary.
For this indication midazolam should be administered i.v.
or i.m., deep into a large muscle mass 20 to 60 minutes before induction of anaesthesia), or preferably via the rectal route in children (see below).
One must wait an additional 2 to 5 minutes to fully evaluate the sedative effect before initiating a procedure or repeating a dose.
If further sedation is necessary, continue to titrate with small increments until the appropriate level of sedation is achieved.
In adults over 60 years, debilitated or chronically ill patients and paediatric patients, dose should be determined with caution and risk factors related to each patient should be taken into account. Additional details are provided in the text following the table.